CGGBP1—an indispensable protein with ubiquitous cytoprotective functions

CGGBP1—an indispensable protein with ubiquitous cytoprotective functions

The human genome contains multiple stretches of CGG trinucleotide repeats, which act as transcription- and translation-regulatory elements but at the same time form secondary structures that impede replication and give rise to sites of chromosome fragility. Proteins binding to such DNA elements may be involved in divergent cellular processes such as transcription, DNA damage, and epigenetic sta...

Cytoprotective and toxic functions of the prion protein family

The cytoprotective protein C pathway.

Protein C is best known for its mild deficiency associated with venous thrombosis risk and severe deficiency associated with neonatal purpura fulminans. Activated protein C (APC) anticoagulant activity involves proteolytic inactivation of factors Va and VIIIa, and APC resistance is often caused by factor V Leiden. Less known is the clinical success of APC in reducing mortality in severe sepsis ...

Robustness of indispensable nodes in controlling protein-protein interaction network

Recently, the structural controllability theory has been introduced to analyze the ProteinProtein Interaction (PPI) network. The indispensable nodes, which their removal increase the number of driver nodes to control the network, are found essential in PPI network. However, the PPI network is far from complete and there may exist many false-positive or false-negative interactions, which promote...

AUP1 (Ancient Ubiquitous Protein 1)

Cardiovascular disease remains the leading cause of death around the world. A major cause is atherogenic dyslipidemia, which is characterized by increased concentrations of triglyceride-rich lipoproteins and is seen in subjects with obesity and type 2 diabetes mellitus. Increased hepatic secretion of triglyceride-rich very-low-density lipoproteins (VLDL) is a major determinant of the hypertrigl...